For its size ingame, and its 6 or 8 engines, ingame it could look quite simple to save polygons, mindue the straight sides of its giant cylindrical body would assist in this.
I'm not sure how the hatches and raising/lowering of the turret system could be easily achieved, maybe only AI controled like Me-210 and AI/playable tail gunner like B-29.
Also, currently the game (4.101m) can only handle 4 designated engines for AI or player control, so 2 props would have to be either just animations or linked to another engine on each wing, i.e; one engine on each wing is powering 2 props (each of those props recieves same power input) as far as 'game engine' is tricked to make it work.
Most airfields and bomber airfields just have too many things close to there short runways that damage the plane - unless special airfeilds made with longer runways (3 - 5 times current ingame full length), with control towers and things/objects that'd damage the plane or get hit would have to be moved away from taxi & runway routes on the 'B-36 airfields'.
This can all be done, but it could take the community time, say a year or two, but boy, golly gee whiz, it'd sure be perty to try and fly (if not 'AI Only')...